Platelet‐Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury
Teng Su, Ke Huang, Hong Ma, Hongxia Liang, Phuong‐Uyen Dinh, Justin Chen, Deliang Shen, Tyler A. Allen, Li Qiao, Zhenhua Li, Shiqi Hu, Jhon Cores, Brianna N. Frame, Ashlyn T. Young, Qi Yin, Jiandong Liu, Li Qian, Thomas G. Caranasos, Yevgeny Brudno, Frances S. Ligler, Ke Cheng* Advanced Functional Materials link to the paper: https://doi.org/10.1002/adfm.201803567
Cardiovascular disease is the leading cause of mortality worldwide. Exploring ways to attenuate I/R injury is of clinical interest for improving post‐ischemic recovery. A platelet‐inspired nanocell (PINC) that incorporates both prostaglandin E2 (PGE2)‐modified platelet membrane and cardiac stromal cell‐secreted factors to target the heart after I/R injury is introduced. By taking advantage of the natural infarct‐homing ability of platelet membrane and the overexpression of PGE2 receptors (EPs) in the pathological cardiac microenvironment after I/R injury, the PINCs can achieve targeted delivery of therapeutic payload to the injured heart. Furthermore, a synergistic treatment efficacy can be achieved by PINC, which combines the paracrine mechanism of cell therapy with the PGE2/EP receptor signaling that is involved in the repair and regeneration of multiple tissues. In a mouse model of myocardial I/R injury, intravenous injection of PINCs results in augmented cardiac function and mitigated heart remodeling, which is accompanied by the increase in cycling cardiomyocytes, activation of endogenous stem/progenitor cells, and promotion of angiogenesis. This approach represents a promising therapeutic delivery platform for treating I/R injury.