Dashuai Zhu, Shuo Liu, Ke Huang, Junlang Li, Xuan Mei, Zhenhua Li, Ke Cheng*. Intrapericardial long non-coding RNA–Tcf21 antisense RNA inducing demethylation administration promotes cardiac repair. European Heart Journal. 14 Mar 2023.


Xianyun Wang, Shiqi Hu, Dashuai Zhu, Junlang Li, Ke Cheng*, Gang Liu*. Comparison of extruded cell nanovesicles and exosomes in their molecular cargos and regenerative potentials. Nano Research. 28 Feb 2023.

Xuan Mei, Junlang Li, Zhenzhen Wang, Dashuai Zhu, Ke Huang, Shiqi Hu, Kristen D. Popowski, Ke Cheng*. An inhaled bioadhesive hydrogel to shield non-human primates from SARS-CoV-2 infection. Nature Materials. 09 Feb 23.



Ke Huang, Ke Cheng*. Sealing the heart from the inside out. Nature Biomedical Engineering. 29 Dec 2022.

Fig. 1

Dashuai Zhu, Shuo Liu, Ke Huang, Zhenzhen Wang, Shiqi Hu, Junlang Li, Zhenhua Li, Ke Cheng*. Intrapericardial Exosome Therapy Dampens Cardiac Injury via Activating Foxo3. Circulation Research. 13 Oct 2022.


Shiqi Hu, Dashuai Zhu, Zhenhua Li, Ke Cheng*. Detachable Microneedle Patches Deliver Mesenchymal Stromal Cell Factor-Loaded Nanoparticles for Cardiac Repair. ACS Nano. 23 Sept 2022.

Miao Fan, Hang Li, Deliang Shen, Zhaoshuo Wang, Huifang Liu, Dashuai Zhu, Zhenzhen Wang, Lanya Li, Kristen D. Popowski, Caiwen Ou, Kaihan Zhang, Jinchao Zhang, Ke Cheng, Zhenhua Li. Decoy Exosomes Offer Protection Against Chemotherapy-Induced Toxicity. Advanced Science. 04 Sept 2022.

Details are in the caption following the image

Jun Fang, Jennifer J.Li, Xintong Zhong, Yue Zhou, Randall J.Lee, Ke Cheng, Song Li. Engineering stem cell therapeutics for cardiac repair. Journal of Molecular and Cellular Cardiology. 18 July 2022.

Weiwei Shi, Xiao Cheng, Ke Cheng*. Gecko-Inspired Adhesives with Asymmetrically Tilting-Oriented Micropillars. Langmuir. 13 July 2022.

Kristen D. Popowski, Adele Moatti, Grant Scull, Dylan Silkstone, Halle Lutz, Blanca López de Juan Abad, Arianna George, Elizabeth Belcher, Dashuai Zhu, Xuan Mei, Xiao Cheng, Megan Cislo, Asma Ghodsi, Yuheng Cai, Ke Huang, Junlang Li, Ashley C. Brown, Alon Greenbaum, Phuong-Uyen C. Dinh, Ke Cheng*. Inhalable dry powder mRNA vaccines based on extracellular vesicles. Matter. 11 July 2022.

Zhenzhen Wang, Kristen D. Popowski, Dashuai Zhu, Blanca López de Juan Abad, Xianyun Wang, Mengrui Liu, Halle Lutz, Nicole De Naeyer, C. Todd DeMarco, Thomas N. Denny, Phuong-Uyen C. Dinh, Zhenhua Li*, Ke Cheng*. Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine. Nature Biomedical Engineering. 04 July 2022.

Screen Shot 2022-07-06 at 15.23.57Volume 6 Issue 7

Kristen D. Popowski, Blanca López de Juan Abad, Arianna George, Dylan Silkstone, Elizabeth Belcher, Jaewook Chung, Asma Ghodsi, Halle Lutz, Jada Davenport, Mallory Flanagan, Jorge Piedrahita, Phuong-Uyen C. Dinh, Ke Cheng*. Inhalable exosomes outperform liposomes as mRNA and protein drug carriers to the lung. Extracellular Vesicle. 16 June 2022.

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Mira Chingale, Ke Cheng* and Ke Huang*. 3D Bioprinting Technology – One Step Closer Towards Cardiac Tissue Regeneration. Frontiers in Materials. 02 Feb 2022.

Chi Zhang, Wei Zhang, Dashuai Zhu, Zhenhua Li, Zhenzhen Wang, Junlang Li, Xuan Mei, Wei Xu*, Ke Cheng* and Biao Zhong*. Nanoparticles functionalized with stem cell secretome and CXCR4-overexpressing endothelial membrane for targeted osteoporosis therapy. Journal of Nanobiotechnology. 15 Jan 2022.

Scheme 1


Yaching Hsu, Ke Huang*, Ke Cheng*. Resuscitating the Field of Cardiac Regeneration: Seeking Answers from Basic Biology. Advanced Biology. 22 Dec 2021.

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Xianyun Wang, Shiqi Hu, Junlang Li, Dashuai Zhu, Zhenzhen Wang, Jhon Cores, Ke Cheng, Gang Liu*, and Ke Huang*. Extruded Mesenchymal Stem Cell Nanovesicles Are Equally Potent to Natural Extracellular Vesicles in Cardiac Repair. ACS Applied Materials & Interfaces. 18 Nov 2021.

Xuan Mei, Dashuai Zhu, Junlang Li, Ke Huang, Shiqi Hu, Zhenhua Li, Blanca López de Juan Abad, and Ke Cheng*. A fluid-powered refillable origami heart pouch for minimally invasive delivery of cell therapies in rats and pigs. Med. 02 Nov 2021.

On the Cover: Myocardial infarction is one of the leading causes of death worldwide.
Current regenerative medicine approaches face a number of shortcomings, limiting their
applicability in the clinic. Advances in biomaterials and stem cell bioengineering
could lead to new therapeutic approaches to recover cardiac function. In this issue,
Mei et al. (pp. 1253–1268) develop an origami-inspired heart pouch for repeated administration
of therapeutics which can be implanted into the pericardial cavity through minimally
invasive surgery. The authors demonstrate its safety and therapeutic potential to
deliver paracrine factors from mesenchymal stem cell after myocardial infarction in
pigs and rats. Cover credit: Maryna Skazochkina/iStock.

Amber Carter, Kristen Popowski, Ke Cheng, Alon Greenbaum, Frances S. Ligler, and Adele Moatti*. Enhancement of Bone Regeneration Through the Converse Piezoelectric Effect, A Novel Approach for Applying Mechanical Stimulation. Bioelectricity. 24 Sep 2021.

FIG. 2.

Sichen Zhang, Dashuai Zhu, Zhenhua Li, Ke Huang, Shiqi Hu, Halle Lutz, Mengjie Xie, Xuan Mei, Junlang Li, Genevieve Neal-Perry, Shaowei Wang*, Ke Cheng*. A stem cell-derived ovarian regenerative patch restores ovarian function and rescues fertility in rats with primary ovarian insufficiency. Theranostics. 18 August 2021.

thno_61690s2_1Issue cover v11i18

Junlang Li, Yongbo Lv, Dashuai Zhu, Xuan Mei, Ke Huang, Xianyun Wang, Zhenhua Li, Sichen Zhang, Shiqi Hu, Kristen D. Popowski, Ke Cheng*, Juan Wang*.Intrapericardial hydrogel injection generates high cell retention and augments therapeutic effects of mesenchymal stem cells in myocardial infarction. Chemical Engineering Journal. 10 August 2021.


Jialu Yao, Ke Huang, Dashuai Zhu, Tan Chen, Yufeng Jiang, Junyi Zhang, Lijie Mi, He Xuan, Shiqi Hu, Junlang Li, Yafeng Zhou, Ke Cheng*. A Minimally Invasive Exosome Spray Repairs Heart after Myocardial Infarction. ACS Nano. 21 June 2021.

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Zhenhua Li, Zhenzhen Wang, Phuong-Uyen C. Dinh, Dashuai Zhu, Kristen D. Popowski, Halle Lutz, Shiqi Hu, Mark G. Lewis, Anthony Cook, Hanne Andersen, Jack Greenhouse, Laurent Pessaint, Leonard J. Lobo, Ke Cheng*. Cell-mimicking nanodecoys neutralize SARS-CoV-2 and mitigate lung injury in a non-human primate model of COVID-19. Nature Nanotechnology. 16 June 2021.

Shiqi Hu, Xianyun Wang, Zhenhua Li, Dashuai Zhu, Jhon Cores, Zhenzhen Wang, Junlang Li, Xuan Mei, Xiao Cheng, Teng Su, Ke Cheng*. Platelet membrane and stem cell exosome hybrids enhance cellular uptake and targeting to heart injury. Nano Today. 08 June 2021.

Mira Chingale, Dashuai Zhu, Ke Cheng*, Ke Huang*. Bioengineering Technologies for Cardiac Regenerative Medicine. Frontiers in Bioengineering and Biotechnology. 03 June 2021.

Junlang Li, Shiqi Hu, Dashuai Zhu, Ke Huang, Xuan Mei, Blanca López de Juan Abad, Ke Cheng*. All Roads Lead to Rome (the Heart): Cell Retention and Outcomes From Various Delivery Routes of Cell Therapy Products to the Heart. Journal of the American Heart Association. 06 April 2021.

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Mengrui Liu, Blanca López de Juan Abad, Ke Cheng*. Cardiac fibrosis: myofibroblast-mediated pathological regulation and drug delivery strategies. Advanced Drug Delivery Reviews. 05 April 2021.


Shiqi Hu, Zhenhua Li, Deliang Shen, Dashuai Zhu, Ke Huang, Teng Su, Phuong-Uyen Dinh, Jhon Cores, Ke Cheng*. Exosome-eluting stents for vascular healing after ischaemic injury. Nature Biomedical Engineering. 05 April 2021.


Dashuai Zhu, Ke Cheng*. Cardiac Cell Therapy for Heart Repair: Should the Cells Be Left Out? Cells. 13 March 2021.


Tyler A Allen, Ke Cheng*. Imaging and Isolation of Extravasation-Participating Endothelial and Melanoma Cells During Angiopellosis. Methods in Molecular Biology. 12 March 2021. DOI: 10.1007/978-1-0716-1205-7_30Fig. 1

Dashuai Zhu, Zhenhua Li, Ke Huang, Thomas G. Caranasos, Joseph S. Rossi, Ke Cheng*. Minimally invasive delivery of therapeutic agents by hydrogel injection into the pericardial cavity for cardiac repair. Nature Communications. 3 March 2021.


Zhenhua Li, Dashuai Zhu, Qi Hui, Jianing Bi, Bingjie Yu, Zhen Huang, Shiqi Hu, Zhenzhen Wang, Thomas Caranasos, Joseph Rossi, Xiaokun Li, Ke Cheng*, Xiaojie Wang*. Injection of ROS‐Responsive Hydrogel Loaded with Basic Fibroblast Growth Factor into the Pericardial Cavity for Heart Repair. Advanced Functional Materials. 4 February 2021.

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Kristen Popowski, Phuong‐Uyen Dinh, Arianna George, Halle Lutz, Ke Cheng*. Exosome therapeutics for COVID‐19 and respiratory viruses. VIEW. 31 January 2021.



Halle Lutz, Kristen Popowski, Phuong-Uyen Dinh, Ke Cheng*. Advanced Nanobiomedical Approaches to Combat Coronavirus Disease of 2019. Advanced NanoBiomed Research. 28 December 2020.

Sichen Zhang, Dashuai Zhu, Xuan Mei, Zhenhua Li, Junlang Li, Mengjie Xie, Halle Lutz, Shaowei Wang*, Ke, Cheng*. Advances in biomaterials and regenerative medicine for primary ovarian insufficiency therapy. Bioactive Materials. 26 December 2020.


Mengjie Xie, Junlang Li, Sichen Zhang, Dashuai Zhu, Xuan Mei, Zhenzhen Wang, Xiao Cheng, Zhenhua Li, Shaowei Wang*, Ke Cheng*. A trifunctional contraceptive gel enhances the safety and quality of sexual intercourse. Bioactive Materials. 3 December 2020.

graphical abstract

Xuan Mei, Ke Cheng*. Recent Development in Therapeutic Cardiac Patches. Frontiers in Cardiovascular Medicine. 27 November 2020.

Figure 1

Pengli Zheng, Miao Fan, Huifang Liu, Yinghua Zhang, Xinyue Dai, Hang Li, Xiaohan Zhou, Shiqi Hu, Xinjian Yang, Yi Jin, Na Yu, Shutao Guo, Jinchao Zhang*, Xing-Jie Liang, Ke Cheng*, Zhenhua Li*. Self-Propelled and Near-Infrared-Phototaxic Photosynthetic Bacteria as Photothermal Agents for Hypoxia-Targeted Cancer Therapy. ACS Nano. 25 November 2020.


Mengrui Liu, Halle Lutz, Dashuai Zhu, Ke Huang, Zhenhua Li, Phuong‐Uyen C. Dinh, Junqing Gao, Yi Zhang, Ke Cheng*. Bispecific Antibody Inhalation Therapy for Redirecting Stem Cells from the Lungs to Repair Heart Injury. Advanced Science. 19 November 2020.

Highlighted in:

Advanced Science News. Link:

antibody-therapy-to-treat-heart-attacks                Screen Shot 2021-01-16 at 10.53.37 AM

Xiao Cheng, Ke Cheng*. Visualizing cancer extravasation: from mechanistic studies to drug development. Cancer and Metastasis Reviews. 6 November 2020. Shot 2020-11-07 at 17.20.32

Teng Su, Ke Huang, Kyle G. Mathews, Valery F. Scharf, Shiqi Hu, Zhenhua Li, Brianna N. Frame, Jhon Cores, Phuong-Uyen Dinh, Michael A. Daniele, Frances S. Ligler, and Ke Cheng*. Cardiac Stromal Cell Patch Integrated with Engineered Microvessels Improves Recovery from Myocardial Infarction in Rats and Pigs. ACS Biomaterials Science & Engineering. 5 October 2020.


Shiqi Hu, Zhenhua Li, Halle Lutz, Ke Huang, Teng Su, Jhon Cores, Phuong-Uyen Cao Dinh, Ke Cheng*. Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling. Science Advances. 24 July 2020. Shot 2020-09-18 at 17.54.04

Kristen Popowski, Halle Lutz, Shiqi Hu, Arianna George, Phuong-Uyen Dinh, Ke Cheng*. Exosome therapeutics for lung regenerative medicine. Journal of Extracellular Vesicles. 29 June 2020. Shot 2020-09-18 at 14.28.54

Junlang Li, Shiqi Hu, Ke Cheng*. Engineering better stem cell therapies for treating heart diseases. Annals of Translational Medicine. 09 May 2020. doi:10.21037/atm.2020.03.44Print

Jhon Cores, Phuong‐Uyen C Dinh, Taylor Hensley, Kenneth B Adler, Leonard J Lobo, Ke Cheng*. A pre‐investigational new drug study of lung spheroid cell therapy for treating pulmonary fibrosis. Stem cells Translational Medicine. 18 April 2020.


Ke  Huang, Emily W Ozpinar, Teng Su, Junnan Tang, Deliang Shen, Li Qiao, Shiqi Hu, Zhenhua Li, Hongxia Liang, Kyle Mathews, Valery Scharf, Donald O Freytes, Ke Cheng*. An off-the-shelf artificial cardiac patch improves cardiac repair after myocardial infarction in rats and pigs. Science Translational Medicine. 08 April 2020.

Screen Shot 2020-09-18 at 17.11.21


Highlighted in:

Nature Medicine. Link:

Nature Reviews Cardiology. Link:

Sydney Stine, Kristen Popowski, Teng Su, Ke Cheng*. Exosome and Biomimetic Nanoparticle Therapies for Cardiac Regenerative Medicine. Current Stem Cell Research & Therapy. 08 March 2020. DOI: 10.2174/1574888×15666200309143924 Screen Shot 2020-09-18 at 16.43.04

Phuong-Uyen C Dinh, Dipti Paudel, Hayden Brochu, Kristen D Popowski, M Cyndell Gracieux, Jhon Cores, Ke Huang, M Taylor Hensley, Erin Harrell, Adam C Vandergriff, Arianna K George, Raina T Barrio, Shiqi Hu, Tyler A Allen, Kevin Blackburn, Thomas G Caranasos, Xinxia Peng, Lauren V Schnabel, Kenneth B Adler, Leonard J Lobo, Michael B Goshe, Ke Cheng*. Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis. Nature communications. 28 February 2020. Shot 2020-09-18 at 16.22.13

Li Qiao, Shiqi Hu, Ke Huang, Teng Su, Zhenhua Li, Adam Vandergriff, Jhon Cores, Phuong-Uyen Dinh, Tyler Allen, Deliang Shen, Hongxia Liang, Yongjun Li, Ke Cheng*. Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs. Theranostics. 10 February 2020. doi: 10.7150/thno.39434Screen Shot 2020-09-18 at 12.04.25

Zhenhua Li, Shiqi Hu, Ke Huang, Teng Su, Jhon Cores, Ke Cheng*. Targeted anti–IL-1β platelet microparticles for cardiac detoxing and repair. Science advances. 5 February 2020.



Shiqi Hu, Zhenhua Li, Jhon Cores, Ke Huang, Teng Su, Phuong-Uyen Dinh, Ke Cheng*.Needle-Free Injection of Exosomes Derived from Human Dermal Fibroblast Spheroids Ameliorates Skin Photoaging. ACS Nano. 26 Aug 2019.

Tyler A. AllenDana AsadEmmanuel AmuM. Taylor HensleyJhon CoresAdam VandergriffJunnan TangPhuong-Uyen DinhDeliang ShenLi QiaoTeng SuShiqi HuHongxia LiangHeather ShiveErin HarrellConnor CampbellXinxia PengJeffrey A. YoderKe Cheng*. Circulating tumor cells exit circulation while maintaining multicellularity augmenting metastatic potential. 

Ke Huang, Zhenhua Li, Teng Su, Deliang Shen, Shiqi Hu, Ke Cheng*. Bispecific Antibody Therapy for Effective Cardiac Repair through Redirection of Endogenous Stem Cells. Advanced Therapeutics. 31 May 2019.


Feiran Liu, Shiqi Hu, Hua Yang, Zhenhua Li, Ke Huang, Teng Su, Shaowei Wang*, Ke Cheng*. Hyaluronic Acid Hydrogel Integrated with Mesenchymal Stem Cell‐Secretome to Treat Endometrial Injury in a Rat Model of Asherman’s Syndrome. Advanced Healthcare Materials. 30 May 2019.

Zhenhua Li, Shiqi Hu, Ke Cheng*. Chemical Engineering of Cell Therapy for Heart DiseasesAcc. Chem. Res. 24 May 2019.

Peisen Huang, Li Wang, Qing Li, Xiaqiu Tian, Jun Xu, Junyan Xu, Yuyan Xiong, Guihao Chen, Haiyan Qian, Chen Jin, Yuan Yu, Ke Cheng, Li Qian*, Yuejin Yang*. Atorvastatin Enhances the Therapeutic Efficacy of Mesenchymal Stem Cells Derived Exosomes in Acute Myocardial Infarction via Up-regulating Long Non-coding RNA H19. Cardiovasc Res. 22 May 2019. doi: 10.1093/cvr/cvz139.

Qiao L, Hu S, Liu S, Zhang H, Ma H, Huang K, Li Z, Su T, Vandergriff A, Tang J, Allen T, Dinh PU, Cores J, Yin Q, Li Y, Cheng K. microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential. J Clinical Investigation. 2019

Liu F, Hu S, Wang S, Cheng K. Biomaterials and cell therapies for uterus regeneration. Regenerative Biomaterials.  rbz021,

Shen D, Li Z, Hu S, Huang K, Su T, Liu F, Cheng K. Antibody-Armed Platelets for Regenerative Targeting of Endogenous Stem Cells. Nano Letter. DOI: 10.1021/acs.nanolett.8b04970 link to the paper

Zhenhua Li, Xiaochen Feng, Shutao Gao, Yan Jin, Wencong Zhao, Huifang Liu, Xinjian Yang, Shiqi Hu, Ke Cheng, and Jinchao Zhang.  Porous Organic Polymers-coated Band-Aids for Phototherapy of Bacteria-induced Wound Infection, ACS Applied Bio Materials  10.1021/acsabm.8b00676. Link to the paper:

Berry JL, Zhu W, Tang YL, Krishnamurthy P, Ge Y, Cooke JP, Chen Y, Garry DJ, Yang HT, Rajasekaran NS, Koch WJ, Li S, Domae K, Qin G, Cheng K, Kamp TJ, Ye L, Hu S, Ogle BM, Rogers JM, Abel ED, Davis ME, Prabhu SD, Liao R, Pu WT, Wang Y, Ping P, Bursac N, Vunjak-Novakovic G, Wu JC, Bolli R, Menasché P, Zhang J. Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure. Circulation Research   2019;124:161–169; Link to the paper


Ke Huang; Shiqi Hu; Ke Cheng. A New Era of Cardiac Cell Therapy: Opportunities and Challenges. Advanced Healthcare Materials.  10.1002/adhm.2018. Link to the paper:

Li Z, Shen D, Hu S, Su T, Huang K, Liu F, Hou L, Cheng K. Pretargeting and Bioorthogonal Click Chemistry-Mediated Endogenous Stem Cell Homing for Heart Repair. ACS Nano. 10.1021/acsnano.8b05892, 2018. link to the paper:

Tang J, Wang J, Huang K, Ye Y, Su T, Qiao L, Hensley MT, Caranasos TG, Zhang J, Gu Z, Cheng K. Cardiac Cell-Integrated Microneedle Patch for Treating Myocardial Infarction. Science Advances,aat9365, 2018. link to the paper:

Quanyin Hu, Wujin Sun, Jinqiang Wang, Huitong Ruan, Xudong Zhang, Yanqi Ye, Song Shen, Chao Wang, Weiyue Lu, Ke Cheng, Gianpietro Dotti, Joshua F. Zeidner, Jun Wang & Zhen Gu*. Conjugation of haematopoietic stem cells and platelets decorated with anti-PD-1 antibodies augments anti-leukaemia efficacy. Nature Biomedical Engineering   link to the paper:

Teng Su, Ke Huang, Hong Ma, Hongxia Liang, Phuong‐Uyen Dinh, Justin Chen, Deliang Shen, Tyler A. Allen, Li Qiao, Zhenhua Li, Shiqi Hu, Jhon Cores, Brianna N. Frame, Ashlyn T. Young, Qi Yin, Jiandong Liu, Li Qian, Thomas G. Caranasos, Yevgeny Brudno, Frances S. Ligler, Ke Cheng* . Platelet‐Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury. Advanced Functional Materials  link to the paper:

afm cover

Xiaolin Cui, Junnan Tang, Yusak Hartanto, Jiabin Zhang, Jingxiu Bi, Sheng Dai, Shi Zhang Qiao, Ke Cheng*, Hu Zhang*. NIPAM-based Microgel Microenvironment Regulates Cardiac Stomal Cells.ACS APPL MATER INTER link to the paper:

  • Su T, Huang K, Daniele MA, Hensley MT, Young A, Tang J, Allen TA, Vandergriff AC, Erb PD, Ligler FS, Cheng K. Cardiac Stem Cell Patch Integrated with Microengineered Blood Vessels Promotes Cardiomyocyte Proliferation and Neovascularization After Acute Myocardial Infarction.  ACS Applied Materials & Interfaces.2018-09-06  link to the paper:

  • Mihako E, Huang K, Sproul Erin, Cheng K, Brown A. Targeted Treatment of Ischemic and Fibrotic Complications of Myocardial Infarction Using a Dual-Delivery Microgel Therapeutic. ACS Nano. July 17, 2018. link to the paper:

Liang H, Huang K, Su T, Li Z, Hu S, Dinh PU, Wrona EA, Shao C, Qiao L, Vandergriff AC, Hensley MT, Cores J, Allen T, Zhang H, Zeng Q, Xing J, Freytes DO, Shen D, Yu Z, Cheng K. Mesenchymal Stem Cell/Red Blood Cell-Inspired Nanoparticle Therapy in Mice with Carbon Tetrachloride-Induced Acute Liver Failure.  ACS Nano. 2018 Jun 26. link to the paper:

Vandergriff A, Huang K, Shen D, Hensley MT, Qian L, Caranasos TG, Cheng K. Targeting regenerative exosomes to myocardial infarction using cardiac homing peptide. Theranostics. 2018; 8(7):1869-1878 (Cover Image) link to the paper: 

Screen Shot 2018-04-24 at 9.18.20 PM

Tang J, Su T, Huang K, Dinh PU, Wang Z, Vandergriff AC, Hensley MT, Cores J, Allen T, Li TS, Sproul E, Mihalko E, Lobo LJ, Ruterbories L, Lynch A, Brown AC, Caranasos TG, Shen D, Stouffer GA, Gu Z, Zhang J, Cheng K. Targeted repair of heart injury by stem cells fused with platelet nanovesicles. Nature Biomedical Engineering. 2, 17–26 (2018) link to the paper: Tang, Jhon Cores, Ke Huang, Xiaolin Cui, Luo Lan, Jinying Zhang, Taosheng Li, Li Qian, Ke Cheng. Concise Review: Is Cardiac Cell Therapy Dead? Embarrassing trial outcomes and new directions for the future. Stem Cells Translational Medicine. 7:354-359, 2018 link to the paper:


Tang J, Cui X, Caranasos TC, Hensley MT, Vandergriff AC, Hartanto Y, Shen D, Zhang H, Zhang J, Cheng K. Heart repair using nanogel encapsulated cardiac stem cells in mice with myocardial infarction. ACS Nano. 2017 Oct 24;11(10):9738-9749 link to the paper:

Cores J, Hensley MT, Kinlaw K, Rikard SM, Dinh PU, Paudel D, Tang J, Vandergriff AC, Allen TA, Li Y, Liu J, Niu B, Chi Y, Caranasos T, Lobo LJ, Cheng K.Safety and Efficacy of Allogeneic Lung Spheroid Cells in a Mismatched Rat Model of Pulmonary Fibrosis. Stem Cells Transl Med. 2017 Aug 7. doi: 10.1002/sctm.16-0374. [Epub ahead of print]

Dinh PC, Cores J, Hensley MT, Vandergriff AC, Tang J, Allen TA, Caranasos TG, Adler KB, Lobo LJ, Cheng K.Derivation of therapeutic lung spheroid cells from minimally invasive transbronchial pulmonary biopsies. Respir Res. 2017 Jun 30;18(1):132. doi: 10.1186/s12931-017-0611-0.

Lan L, Tang J, Nishi K, Yan C, Dinh PU, Cores J, Kudo T, Zhang J, Li T, and Cheng K. Fabrication of Synthetic Mesenchymal Stem Cells for the Treatment of Acute Myocardial Infarction in Mice.  Circulation Research. 2017Mar 15. pii: CIRCRESAHA.116.310374. doi: 10.1161/CIRCRESAHA.116.310374

Circulation Research Cover

Tang J, Shen D, Caranasos TG, Wang Z, Allen TA, Vandergriff A, Hensley MT, Dinh PU, Cores J, Li TS, ZhangJ, Kan Q, and Cheng K. Therapeutic microparticles functionalized with biomimetic cardiac stem cell membranes and secretome. Nature Communications. 2017 Jan 3;8:13724. doi: 10.1038/ncomms13724

Tang J, Vandergriff A, Wang Z, Hensley M, Cores J, Allen T, Dinh PU, Zheng J, Caranasos T, Cheng K. A Regenerative Cardiac Patch Formed by Spray Painting of Biomaterials onto the Heart. Tissue Engineering 2017 Jan 9. doi: 10.1089/ten.TEC.2016.0492    

MT Hensley, Tang J, Woodruff K, Defrancesco T, Tou S, Williams CM, Breen M, Meurs K, Keene B, Cheng K. Intracoronary allogeneic cardiosphere-derived stem cells are safe for use in dogs with dilated cardiomyopathy. J Cell Mol Medicine 2017 Mar 15. doi: 10.1111/jcmm.13077

Wang Z, Dong N, Wu Q, Cheng K. Transplantation of human villous trophoblasts preserves cardiac function in mice with acute myocardial infarction. J Cell Mol Med. Accepted February 2017.


Allen TA, Gracieux D, Talib M, Tokarz DA, Hensley MT, Cores J, Vandergriff A, Tang J, de Andrade JB, Dinh PU, Yoder JA, Cheng K. “Angiopellosis as an Alternative Mechanism of Cell Extravasation.” Stem Cells. 2016 Jun 28.

Shen D, Tang J, Hensley MT, Li T, Caranasos TG, Zhang T, Zhang J, Cheng K. “Effects of Matrix Metalloproteinases on the Performance of Platelet Fibrin Gel Spiked With Cardiac Stem Cells in Heart Repair.” Stem Cells Translational Medicine. 2016 Apr 25.


Andrade JN, Tang J, Hensley MT, Vandergriff A, Cores J, Henry E, Allen TA, Caranasos TG, Wang Z, Zhang T, Zhang J, Cheng K. “Rapid and Efficient Production of Coronary Artery Ligation and Myocardial Infarction in Mice Using Surgical Clips.” PLoS One. 2015 Nov 24; 10(11):e0143221.

Vandergriff A, de Andrade JB, Tang J, Hensley MT, and Cheng K. “Intravenous administration of cardiac progenitor cell-derived exosomes mediates heart regeneration after doxorubicin-induced dilated cardiomyopathy.” Stem Cell International. 2015. Epub 2015 August 17.

Tang J, Shen D, Zhang J, Ligler FS, Cheng K. “Bispecific antibodies, nanoparticles and cells: bringing the right cells to get the job done.” Expert Opinion on Biological Therapies. 2015;15(9):1251-5

Cores J, Caranasos TG, Cheng K. “Magnetically Targeted Stem Cell Delivery for Regenerative Medicine.” Journal of Functional Biomaterials. 2015 June 6.

Henry E, Cores J, Hensley MT, Anthony S, Vandergriff A, de Andrade JBM, Allen T, Caranasos TG, Lobo LJ, Cheng K. “Adult Lung Spheroid Cells Contain Progenitor Cells and Mediate Regeneration in Rodents with Bleomycin-Induced Pulmonary Fibrosis.” Stem Cells Translational Medicine. 2015.

Vandergriff A, Hensley TM, Cheng K. “Cryopreservation of Cardiomyocytes.” Methods in Molecular Biology. 1299:153-60. 2015.

Hensley MT, de Andrade J, Meurs K, Keene B, Tang J, Piedrahita J, Caranasos TG, Li TS, Cheng K. “Regenerative potential of canine cardiac stem cells.” Journal of Cellular and Molecular Medicine. 19(8):1805-13. 2015.

Vandergriff A, Hensley MT, Cheng K. “Cryoperservation of cardiomyocytes for cell-based assay.” Journal of Visual Experiments. 2015.

Kanazawa H, Tseliou E, Malliaras K, Yee K, Dawkins JF, De Couto G, Smith RR, Kreke M, Seinfeld J, Middleto RC, Cheng K, Luthringer D, Valle I, Chowdhury S, Fukuda K, Makkar RR, Marbán L . “Cellular post-conditioning: allogeneic cardiosphere-derived cells reduce infarct size and attenuate microvascular obstruction when administered after reperfusion in pigs with acute myocardial infarction.” Circulation Heart Failure. 8(2):322-32. 2015.


Vandergriff A, Hensley TM, Henry ET, Shen D, Anthony S, Zhang J, Cheng K. “Magnetic targeting of cardiosphere-derived stem cells with ferumoxytol nanoparticles for treating rats with myocardial infarction.” Biomaterials. 35:8528-39. 2014.

Cheng K (co-corresponding), Ibrahim A, Hensley MT, Sun B, Liu W, Smith RR, Marbán E. “CD90/Thy-1-negative cardiosphere-derived cells exhibit augmented regenerative potency in humans and mice with myocardial infarction.” Journal of the American Heart Association. 2014. In press.

Cheng K (co-corresponding), Shen D, Hensley TM, Sun D, Malliaras K, De Couto G, Middleton RC, Marbán E . “Magnetic antibody-linked nanomatchmakers for therapeutic cell targeting.” Nature Communications. 5:4880. 2014.

Xie Y, Ibrahim A, Cheng K, Malliaras K, Shen D, Sun B, Cho HC, Marbán E . “Human Cardiosphere-derived Cells Stimulate Cardiomyocyte Proliferation via β1 Integrin Signaling.” Stem Cells. 2014. Epub ahead of print.

Ibrahim A, Cheng K, Marbán E . “Exosomes as critical agents of cardiac regeneration triggered by cell therapy.” Stem Cell Reports. 2:606-19. 2014.

Aminzadeh MA, Tseliou E, Sun B, Cheng K, Malliaras K, Makkar RR, Marbán E . “Therapeutic efficacy of cardiosphere-derived cells in a transgenic mouse model of nonischemic dilated cardiomyopathy.” European Heart Journal. 2014.Epub ahead of print.

Cheng K, Malliaras K, Smith RR, Shen D Sun B, Blusztajn A, Xie Y, Ibrahim A, Aminzadeh MA, Liu W, Li TS, De Robertis MA, Marbán L, Czer LS, Trento A, Marbán E . “Human cardiosphere-derived cells from advanced heart failure patients exhibit augmented functional potency in a mouse model of myocardial infarction.” Journal of the American College of Cardiolology Heart Failure. 2:49-61. 2014.

Malliaras K, Makkar RR, Smith RR, Cheng K, Wu E, Bonow RO, Marbán L, Mendizabal A, Cingolani E, Johnston PV, Gerstenblith G, Schuleri KH, Lardo AC, Marbán E . “Intracoronary cardiosphere-derived cells after myocardial infarction: evidence of therapeutic regeneration in the final 1-year results of the CADUCEUS trial (CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction).” Journal of the American College of Cardiolology. 63:110-22. 2014.


Malliaras K, Zhang Y, Seinfeld J, Galang G, Tseliou E, Cheng K, Sun B, Aminzadeh M, Marbán E . “Cardiomyocyte proliferation and progenitor cell recruitment underlie therapeutic regeneration after myocardial infarction in the adult mouse heart.” EMBO Molecular Medicine. 5:191-209. 2013.

Malliaras K, Smith RR, Kanazawa H, Yee K, Seinfeld J, Tseliou E, Dawkins JF, Kreke M, Cheng K, Luthringer D, Ho CS, Blusztajn A, Valle I, Chowdhury S, Makkar RR, Dharmakumar R, Li D, Marbán L, Marbán E . “Validation of contrast-enhanced MRI to monitor regenerative efficacy after cell therapy in a porcine model of convalescent myocardial infarction.” Circulation. 128:2764-75. 2013.


Makkar RR, Smith RR, Cheng K, Malliaras K, Thomson LE, Berman D, Czer LS, Marbán L, Mendizabal A, Johnston PV, Russell SD, Schuleri KH, Lardo AC, Gerstenblith G, Marbán E . “Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial.” Lancet. 379:895-904. 2012.

Cheng K, Blusztajn A, Shen D, Li TS, Sun B, Galang G, Zarembinski TI, Prestwich GD, Marbán E, Smith RR, Marbán L . “Functional performance of human cardiosphere-derived cells delivered in an in situ polymerizable hyaluronan-gelatin hydrogel.” Biomaterials. 33:5317-24. 2012.

Shen D, Cheng K (co-corresponding author), Marbán E . “Dose-dependent functional benefit of human cardiosphere transplantation in mice with acute myocardial infarction.” Journal of Cellular and Molecular Medicine. 16:2112-6. 2012.

Cheng K, Shen D, Xie Y, Cingolani E, Malliaras K, Marbán E . “Mechanism of extravasation of infused regenerative cells from microvessels into tissue parenchyma.” Stem Cells. 30:2835-42. 2012.

Lai Y, Cheng K (co-first author), Kisaalita WS . “Three Dimensional Neuronal Cell Cultures More Accurately Model Voltage Gated Calcium Channel Functionality in Freshly Dissected Nerve Tissue.” Plos One. 7:e45074. 2012.

Cheng K, Malliaras K, Shen D, Smith J, Houde C, Galang G, Sun B, Marbán E . “Intramyocardial injection of platelet gel promotes endogenous repair and augments cardiac function in rats with myocardial infarction.” Journal of the American College Cardiology. 59:245-53. 2012.

Cheng K, Shen D, Smith J, Galang G, Sun B, Zhang J, Marbán E . “Transplantation of platelet gel spiked with cardiosphere-derived cells boosts structural and functional benefits relative to gel transplantation alone in rats with myocardial infarction.” Biomaterials. 33:2872-9. 2012.

Cheng K, Blusztajn A, Shen D, Li TS, Sun B, Galang G, Zarembinski TI, Prestwich GD, Marbán E, Smith RR, Marbán L . “Functional performance of human cardiosphere-derived cells delivered in a Hyaluronan-Gelatin hydrogel.” Biomaterials. 33:5317-24. 2012.

Cheng K, Malliaras K, Li T-S, Sun B, Houde C, Galang G, Matsushita N, Marbán E . “Magnetic enhancement of cell retention, engraftment and functional benefit after intracoronary delivery of cardiac-derived stem cells in a rat model of ischemia/reperfusion.” Cell Transplantation. 21:1121-35. 2012.

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